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Plenhyage XL

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Disclaimer: results may vary between individuals
Face Treatments

Welcome to the future of skin regeneration!

Plenhyage XL is injectable treatment that revolutionises the way we think about maintaining healthy skin. It works at a cellular level to repair and regenerate tissue and is a great option for men and women in Essex and in London who are looking to improve their skin’s vibrancy, tone, and texture. From acne to rosacea and from age spots to sun damage, this promises to be an excellent way to rejuvenate the appearance of your skin. Plenhyage XL activates fibroblasts, encouraging cell turnover which leads to firmer and more hydrated looking skin, softening the signs of ageing including ‘Crepe-like’ skin and fine lines and wrinkles.

The evolution of polynucleotides in regenerative medicine

When it comes to skin health and anti-ageing, innovation is key.  Dr Ioannis Liakas, Medical director at Vie Aesthetics Rayleigh and in London, explains: “With its breakthrough formulation of polynucleotides (PDRN), Plenhyage XL promises to be the next big thing in skin regeneration. It is incredibly effective in both preventing and treating signs of ageing such as wrinkles, fine lines, dark circles under the eyes, uneven skin tone, and dullness, but it is also a great tool for our doctors to reduce acne scarring as well as hyperpigmentation due to sun exposure.”


So, what is Plenhyage XL?

Unlike dermal fillers and skin boosters using traditional hyaluronic acid, Plenhyage XL is a solution of Polynucleotides (PDRNs) – the building blocks of protein. These are responsible for activating cell functions, promoting hyaluronic acid synthesis, stimulating fibroblast growth, and boosting collagen production.  And that’s not all.  PlenhyageXL injections act on two levels: Prevention and Repair. Yes, these oligo-peptides have been scientifically proven to be highly effective at repairing damaged tissues, stimulating fibroblasts, and increasing moisture levels in the skin.

How does Plenhyage XL work?

Plenhyage XL uses DNA to alter the behaviour of the skin cells and promote collagen production. The polynucleotide chain in Plenhyage XL  in addition to attracting water molecules, has an anti-free radical action, acting as a scavenger of OH hydroxyl radicals which tend to accumulate as a result of stress, cell damage, external agents such as UV rays. The moisturizing action and anti-free radical activity help to create an optimal environment for the growth of fibroblasts, helping to restore the elasticity of the tissues. As a result, Plenhyage XL helps reduce wrinkles, fine lines, age spots, sagging, and other signs of aging while promoting healthier looking skin.


Why Plenhyage XL?

A good reason to opt for Plenhyage XL is the fact that this is a medical grade injectable skin boosting solution that repairs and regenerates skin tissue. Different from Hyaluronic Acid skin boosters, the polynucleotides in Plenhyage XL make it a higly versatile product with a host of potential applications.  This means that we can provide skin tightening and skin smoothing, without any deep structural injections.

Who is Plenhyage XL  for?

Plenhyage XL this is perfect for patients who need a general improvement in skin quality or particular lesions they want to improve. It is very beneficial for rejuvenating the face, including the under-eye area. As well as being injected into the upper, mid and lower face, Plenhyage XL can also treat the neck, décolletage, inner arms, thighs, and knees.  It can improve skin overall and help with age spots, UV spots, acne scarring, and sun damage spots.

How can you get this?

The Plenhyage XL treatment is performed only by medical practitioners and is available in all our clinics.  Note that procedures can also be combined with other  treatments like Morpheus8 for an optimal outcome. This treatment is also ideal for preparing the facial skin for other aesthetic medicine treatments.

So, if you want to take your skincare routine up a notch then Plenhyage XL may be worth considering!

For more information, book your consultation now. You can do this online by clicking BOOK NOW above,  Call 07899673578 , or Email [email protected]

We also offer interest free finance on treatments above £280 and on selected packages.

Please call us on 0207 1646140 or 07899 673578 to find out more, or submit an enquiry below.

Want to book a consultation or ask us a question? Simply click on the relevant button below.

Submit Enquiry

Avoid alcohol consumption for 24 hours before and after your treatment.

Immediately after the treatment, there may be slight redness, swelling, bruising, tenderness, and an itching sensation in the treated area.

These will be temporary and generally disappear within a few days. If it continues or if you experience other reactions, please contact us.

Avoid touching the treated area for 6 hours after the treatment. After that ,the area can be washed with a gentle cleanser.

Avoid makeup or cream on the treated area for 24 hours.

Until the initial swelling and redness have resolved

  • do not expose the treated area to intense heat (e.g., sauna, steam rooms, hot showers, and sunbathing) or extreme cold.
  • do not massage the treated area.
  • avoid strenuous exercise and swimming to avoid risks of infection.

Avoid alcohol consumption for 24 hours before and after your treatment.

Apply SPF50. Stay hydrated.

Schedule your next visit in 21 days.

How many sessions will I need?

We generally recommend 2-3 treatments,  2-4 weeks apart, but our treatmetnes are tailored to meet individual needs. Therefore, how many sessions you require will depend on your own goals and needs, as well as the size of the area(s) being treated. For optimal results, your practitioner will advise you on the likely course of action during your initial, no-obligation consultation. Your progress will also be monitored during ongoing free reviews.

How long do the results of Plenhyage XL last?

The results from Plenhyage XL are long lasting, in general six to nine months, as long as the suggested after-care is properly followed. We would recommend regular treatments to keep your skin in great condition.

Does the Plenhyage XL treatment hurt?

The pins are minuscule and a local anaesthetic is applied to numb the treatment area. You may experience some discomfort during procedures, but this will be minimal and our doctor will try to make treatment as comfortable as possible.

Are Plenhyage XL treatments safe?

The Plenhyage XL procedure is very safe and minimally invasive treatment with excellent results, especially for those individuals who want to avoid structural fillers, but instead prefer general skin rejuvenation and healing.

What is the downtime of Plenhyage XL treatments?

This treatment requires around 3-7 days of downtime, due to the potential redness,  mild needle pin like swelling and possibly mild bruising. This can be easily covered with make-up.

When should I expect to see results?

You can expect to see results after around three weeks after the treatment and your skin quality will improve gradually as the tissues regenerate. You’ll definitely notice the difference after 2-4 weeks, and results will develop for several months, as this is a regenerative treatment. Full results can be expected about 3 months after treatment.

Are there research and clinical results ?

Clinical studies have shown:

  • 115% increase in skin hydration
  • 38% increase in skin elasticity
  • Reduction in inflammatory redness and improvement in rosacea and acne
  • Improvement in acne scarring
  • Reduction in pigmentation resulting from sun exposure
  • Over 50% increase in skin thickness
  • 47% increase in collagen production
Is the treatment cruelty free?

The gel contains small fragments of DNA derived from salmon. It is cruelty-free.

What are the beneficial effects of PDRN (Polydeoxyribonucleotides) contained in Plenhyage?


  1. are regenerative
  2. have anti-nflammatory action
  3. stimulate cell proliferation
  4. promote synthesis of collagen and elastin
  5. promote synthesis of Hyaluronic Acid
  6. induce angiogenesis
  7. inhibit melanogenesis
  8. restore  and stimulate fibroblast biosynthesis

Please note that results vary from person to person due to lifestyle, external and internal factors, and genetic predispositions.

Vie Aesthetics Clinics

95 Gray’s Inn Rd,


Harley Street

2 Harley Street,


78 London Hill Road,




Marktgasse 5,
71332 Waiblingen,


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