Article by
Vicky Grammatikopoulou, BHons, MA, PGCE
Vicky Grammatikopoulou is the founder and CEO of Vie Aesthetics, a multi-award winning UK-based aesthetics business built on a philosophy of safety, excellence, education, innovation, and empowerment.
The most effective treatment for your eyes might not be the one you’ve heard the most about. When deciding between skin boosters, profhilo, polynucleotides for thinning under-eye skin, polynucleotides are typically the better choice because they focus on cellular repair rather than just surface hydration. While skin boosters, profhilo, polynucleotides all improve skin quality, polynucleotides are specifically engineered to regenerate the delicate tissue found in the periorbital area, which is the skin surrounding the eyes.
It’s frustrating to see dullness and a loss of elasticity despite using quality skincare. You deserve clarity on which injectable will actually deliver that firmer, more resilient texture you’re looking for. Discover the distinct benefits of injectable moisturisers and regenerative DNA treatments to find your perfect match for a natural, refreshed glow.
The skin around our eyes is significantly thinner than the rest of the face, which requires a more precise, bespoke approach. We’ll break down the science of bio-remodelling versus bio-regeneration to help you make an empowered decision for your skin health and long-term rejuvenation. This guide ensures you feel confident in choosing a path that respects your unique anatomy and aesthetic goals.
The primary difference lies in their core function: skin boosters hydrate, Profhilo remodels, and polynucleotides regenerate. When comparing skin boosters, profhilo, polynucleotides, we see they are all “injectable moisturisers” that improve the skin from within without adding the structural volume seen with dermal fillers. Each option serves a unique purpose in a bespoke skin plan.
Our Medical Director, Dr Ioannis Liakas, provides the clinical expertise needed to compare these advanced options. He emphasises that whilst they share some similarities, their biological mechanisms are distinct. Understanding these differences is the first step toward achieving a natural, refreshed appearance.
We categorise skin boosters as hyaluronic acid (HA) injections that function as internal moisturisers. Unlike topical creams that sit on the surface, these micro-injections deliver hydration directly into the dermis, which is the deeper layer of your skin. This process significantly improves skin texture and creates a visible “glow.”
These treatments are particularly popular amongst younger patients or anyone noticing the first signs of dehydration. By replenishing HA levels, skin boosters help maintain a supple and fresh complexion. They offer a subtle enhancement that makes the skin look well-rested and healthy.
Profhilo is unique because it contains one of the highest concentrations of pure hyaluronic acid on the market. It isn’t just about moisture; it acts as a bio-remodeller. This means it stimulates the production of four different types of collagen and elastin, which are the essential proteins that give your skin its structure.
We use the BAP (Bio Aesthetic Points) technique to administer Profhilo. This is a standardised protocol involving five specific injection points on each side of the face. It ensures the product spreads evenly and safely across the tissues, addressing skin laxity and providing a gentle lifting effect without the use of traditional fillers.
Polynucleotides, such as Plenhyage XL, represent the next generation of regenerative aesthetics. These are DNA fractions derived from salmon that work at a cellular level. By understanding what are polynucleotides?, we can see how these biopolymers signal fibroblasts to repair damaged tissue and increase overall elasticity.
Fibroblasts are the specific cells responsible for creating new skin tissue. Polynucleotides are especially favoured for the thin under-eye skin because they can improve dark circles and fine lines by strengthening the skin’s foundation. They don’t just mask concerns; they encourage the skin to behave like a younger version of itself.
Choosing the right treatment requires a look at how your cells communicate. Dr Ioannis Liakas explains that “the science of cellular signalling is the foundation of modern aesthetics; we aren’t just filling gaps, we’re instructing the skin to behave more youthfully.” This distinction is why we use terms like bio-remodelling for Profhilo and bio-regeneration for polynucleotides. Whilst both fall under the broad clinical classifications of skin boosters, they target different biological pathways.
A doctor-led approach is vital here. Only a qualified medical practitioner can assess whether your skin needs the structural remodelling of high-concentration HA or the deep cellular repair of DNA fragments. By targeting the correct pathway, we ensure results look natural and respect your unique anatomy. If you’re unsure which biological pathway your skin needs, book a skin assessment with our expert team to find your bespoke solution.
Hyaluronic acid (HA) is a powerhouse molecule naturally found in our bodies. It can hold up to 1,000 times its own weight in water. When we use skin boosters, profhilo, polynucleotides, the HA-based versions provide an immediate plumping effect by saturating the dermis with moisture. This isn’t a filler; it doesn’t add volume or change your facial shape. Instead, it creates a healthier environment for your cells to thrive, leading to long-term skin health and improved elasticity.
Polynucleotides take a different approach to skin health. These purified DNA fractions act as bio-stimulators that excel at wound healing and reducing inflammation. This makes them incredibly effective for sensitive areas like the under-eyes. By improving the extracellular matrix, which is the scaffolding of your skin, they build long-term resilience and firmness.
We often recommend polynucleotides for more than just ageing concerns. They’re excellent for managing rosacea or improving the appearance of scarring because they repair the skin’s foundation at a DNA level. This regenerative power ensures the skin becomes thicker and more resilient over time, providing a refreshed look that feels entirely your own.
Managing expectations is a cornerstone of the Vie Aesthetics philosophy. Because regenerative aesthetics rely on your body’s biological response, results are gradual and vary between individuals. As highlighted in the feature on Polynucleotides explained by Harper’s Bazaar, these treatments are a commitment to long-term skin health rather than a quick change. Understanding the capabilities of skin boosters, profhilo, polynucleotides ensures you remain the lead architect of your own aesthetic journey.
Dr Ioannis Liakas emphasises the importance of a realistic approach: “At Vie Aesthetics, we believe in celebrating natural beauty. Our goal is to use regenerative science to support the skin’s own repair mechanisms, ensuring you look like a refreshed version of yourself rather than a different person entirely.”
These treatments excel at enhancing the quality of your skin from the inside out. You can expect a visible improvement in luminosity and what many describe as a “lit-from-within” dewiness. Whilst they aren’t fillers, the increased hydration and collagen stimulation can lead to a subtle tightening of mild skin laxity. The result is a natural-looking refresh that avoids the “pillow face” look sometimes associated with over-filled areas.
It’s vital to recognise the limitations of non-surgical injectables. These treatments won’t replace the structural lift provided by a surgical facelift or advanced laser procedures like Endolift. They don’t provide the dramatic volume or contouring of traditional dermal fillers, as their purpose is tissue quality rather than shape modification. Furthermore, results aren’t permanent; maintenance sessions are required to keep your cellular health at its peak.
Myth vs Reality
There is a common myth that results are “instant.” In reality, collagen synthesis is a biological process that takes time to unfold, typically showing the best results several weeks after your initial course. Another misconception involves the “salmon smell” of polynucleotides. Reality: the DNA fractions are ultra-purified and clinical-grade, meaning they are completely odourless and biocompatible.
Every successful skin journey begins with a detailed consultation. This essential first step allows us to understand your goals and assess the unique biology of your skin. We don’t believe in a one-size-fits-all approach; instead, we create a personalised plan that might incorporate skin boosters, profhilo, polynucleotides based on what your tissue specifically requires for a natural, refreshed glow.
Consistency is the secret to long-term results. To support your clinical treatments, we recommend the VieDerma Skincare Range for home maintenance. This ensures your skin remains nourished and protected between clinic visits. To make ongoing care more manageable, our Vie Membership scheme offers tiers from Bronze to Diamond, providing a structured way to prioritise your skin health throughout the year.
We believe that premium, doctor-led care should be accessible. For any treatment plans starting from £280, we offer interest-free finance options. This allows you to focus on your transformation whilst managing the investment at a pace that suits you. Our team is here to guide you through every stage, from the initial assessment to the final, glowing result.
In many cases, the most effective rejuvenation comes from combining different therapies. We often find that using Profhilo to address mid-face laxity whilst simultaneously using polynucleotides for the delicate under-eye area yields the most balanced outcome. This holistic strategy is at the heart of the “VieLift,” our signature combination approach that targets multiple layers of the skin for a comprehensive refresh. You can explore how we integrate these options in our comprehensive guide to non-surgical treatments.
Your safety is never compromised. At Vie Aesthetics, all injectable treatments are performed exclusively by doctors or qualified medical practitioners. This medical oversight ensures that every procedure is conducted with precision and a deep understanding of facial anatomy. Our 2023 CQC inspection, which highlighted our “Best Customer Service,” serves as a mark of the trust and safety we provide to every client who walks through our doors.
Choosing between skin boosters, profhilo, polynucleotides requires a clinical understanding of how your skin ages at a cellular level. We’ve explored how polynucleotides focus on deep tissue repair whilst Profhilo excels at bio-remodelling for improved elasticity. Both treatments offer a sophisticated path to rejuvenation without the need for traditional fillers or artificial volume. Your skin deserves a plan that respects its unique biology and your personal aesthetic goals.
At Vie Aesthetics, our CQC-regulated clinics prioritise your safety and professional integrity above all else. Every procedure is performed exclusively by medical doctors who specialise in creating bespoke, natural-looking transformations tailored to your anatomy. To make your journey even smoother, we provide interest-free finance options for treatments over £280. This ensures you can prioritise your skin health with complete peace of mind and financial flexibility.
You don’t have to navigate these choices alone. Our dedicated team is here to support you in finding the perfect match for your skin’s needs, ensuring you feel confident and empowered at every stage of your transformation.
The investment for these procedures depends on the specific brand of product selected and the number of sessions required for your individual goals. Most regenerative protocols involve an initial course of two or three treatments to build the necessary collagen and hydration. During your bespoke consultation, we provide a detailed plan and a clear breakdown of the costs involved. We also offer interest-free finance for plans over £280 to support your skin journey.
Results from these regenerative treatments are long-lasting but not permanent. Most patients enjoy the effects of Profhilo for approximately six months before a single maintenance session is recommended to sustain the tissue remodelling. Polynucleotides follow a similar timeline, with the cellular repair benefits typically lasting around six months. Individual lifestyle factors, such as sun exposure and skincare routines, will influence how long your skin maintains its improved resilience and hydration levels after your sessions.
Downtime is generally minimal, though you may experience slight swelling or small bumps at the injection sites for 24 to 48 hours. These bumps are simply the product settling into the dermis and usually dissipate quickly. Some patients might notice minor bruising, especially in the delicate under-eye area. We advise avoiding strenuous exercise, saunas, or heavy makeup for the first 24 hours to ensure the skin heals beautifully and without any unnecessary irritation or risk.
Yes, combining these treatments is often the most effective way to address multiple skin concerns simultaneously. Whilst Profhilo works to remodel the mid-face and improve overall laxity, polynucleotides can specifically target the thin skin around the eyes. This layered approach allows us to utilise the hydration of hyaluronic acid alongside the regenerative power of DNA fragments. Your doctor will design a bespoke schedule during your consultation to ensure each treatment has the space to work optimally.
Polynucleotides are derived from salmon DNA, so they are generally avoided if you have a known fish or seafood allergy. Whilst the DNA fractions undergo an ultra-purification process to remove proteins, safety remains our absolute priority. During your initial consultation, we’ll thoroughly review your medical history and allergies. If polynucleotides aren’t suitable, we can explore alternative skin boosters, profhilo, polynucleotides options that use hyaluronic acid to achieve similar hydrating and refreshing results safely.
For most skin boosters, profhilo, polynucleotides, an initial course is necessary to build the foundation for your results. Profhilo typically requires two sessions spaced four weeks apart. Polynucleotides often involve a course of three treatments at three-week intervals to achieve significant cellular repair. Whilst some patients notice a subtle improvement after the first visit, the full glow and improved skin texture usually become visible a few weeks after the final session of your specific treatment protocol.
Article by
Vicky Grammatikopoulou, BHons, MA, PGCE
Vicky Grammatikopoulou is the founder and CEO of Vie Aesthetics, a multi-award winning UK-based aesthetics business built on a philosophy of safety, excellence, education, innovation, and empowerment.
The most effective treatment for your eyes might not be the one you’ve heard the most about. When deciding between skin boosters, profhilo, polynucleotides for thinning under-eye skin, polynucleotides are typically the better choice because they focus on cellular repair rather than just surface hydration. While skin boosters, profhilo, polynucleotides all improve skin quality, polynucleotides are specifically engineered to regenerate the delicate tissue found in the periorbital area, which is the skin surrounding the eyes.
It’s frustrating to see dullness and a loss of elasticity despite using quality skincare. You deserve clarity on which injectable will actually deliver that firmer, more resilient texture you’re looking for. Discover the distinct benefits of injectable moisturisers and regenerative DNA treatments to find your perfect match for a natural, refreshed glow.
The skin around our eyes is significantly thinner than the rest of the face, which requires a more precise, bespoke approach. We’ll break down the science of bio-remodelling versus bio-regeneration to help you make an empowered decision for your skin health and long-term rejuvenation. This guide ensures you feel confident in choosing a path that respects your unique anatomy and aesthetic goals.
The primary difference lies in their core function: skin boosters hydrate, Profhilo remodels, and polynucleotides regenerate. When comparing skin boosters, profhilo, polynucleotides, we see they are all “injectable moisturisers” that improve the skin from within without adding the structural volume seen with dermal fillers. Each option serves a unique purpose in a bespoke skin plan.
Our Medical Director, Dr Ioannis Liakas, provides the clinical expertise needed to compare these advanced options. He emphasises that whilst they share some similarities, their biological mechanisms are distinct. Understanding these differences is the first step toward achieving a natural, refreshed appearance.
We categorise skin boosters as hyaluronic acid (HA) injections that function as internal moisturisers. Unlike topical creams that sit on the surface, these micro-injections deliver hydration directly into the dermis, which is the deeper layer of your skin. This process significantly improves skin texture and creates a visible “glow.”
These treatments are particularly popular amongst younger patients or anyone noticing the first signs of dehydration. By replenishing HA levels, skin boosters help maintain a supple and fresh complexion. They offer a subtle enhancement that makes the skin look well-rested and healthy.
Profhilo is unique because it contains one of the highest concentrations of pure hyaluronic acid on the market. It isn’t just about moisture; it acts as a bio-remodeller. This means it stimulates the production of four different types of collagen and elastin, which are the essential proteins that give your skin its structure.
We use the BAP (Bio Aesthetic Points) technique to administer Profhilo. This is a standardised protocol involving five specific injection points on each side of the face. It ensures the product spreads evenly and safely across the tissues, addressing skin laxity and providing a gentle lifting effect without the use of traditional fillers.
Polynucleotides, such as Plenhyage XL, represent the next generation of regenerative aesthetics. These are DNA fractions derived from salmon that work at a cellular level. By understanding what are polynucleotides?, we can see how these biopolymers signal fibroblasts to repair damaged tissue and increase overall elasticity.
Fibroblasts are the specific cells responsible for creating new skin tissue. Polynucleotides are especially favoured for the thin under-eye skin because they can improve dark circles and fine lines by strengthening the skin’s foundation. They don’t just mask concerns; they encourage the skin to behave like a younger version of itself.
Choosing the right treatment requires a look at how your cells communicate. Dr Ioannis Liakas explains that “the science of cellular signalling is the foundation of modern aesthetics; we aren’t just filling gaps, we’re instructing the skin to behave more youthfully.” This distinction is why we use terms like bio-remodelling for Profhilo and bio-regeneration for polynucleotides. Whilst both fall under the broad clinical classifications of skin boosters, they target different biological pathways.
A doctor-led approach is vital here. Only a qualified medical practitioner can assess whether your skin needs the structural remodelling of high-concentration HA or the deep cellular repair of DNA fragments. By targeting the correct pathway, we ensure results look natural and respect your unique anatomy. If you’re unsure which biological pathway your skin needs, book a skin assessment with our expert team to find your bespoke solution.
Hyaluronic acid (HA) is a powerhouse molecule naturally found in our bodies. It can hold up to 1,000 times its own weight in water. When we use skin boosters, profhilo, polynucleotides, the HA-based versions provide an immediate plumping effect by saturating the dermis with moisture. This isn’t a filler; it doesn’t add volume or change your facial shape. Instead, it creates a healthier environment for your cells to thrive, leading to long-term skin health and improved elasticity.
Polynucleotides take a different approach to skin health. These purified DNA fractions act as bio-stimulators that excel at wound healing and reducing inflammation. This makes them incredibly effective for sensitive areas like the under-eyes. By improving the extracellular matrix, which is the scaffolding of your skin, they build long-term resilience and firmness.
We often recommend polynucleotides for more than just ageing concerns. They’re excellent for managing rosacea or improving the appearance of scarring because they repair the skin’s foundation at a DNA level. This regenerative power ensures the skin becomes thicker and more resilient over time, providing a refreshed look that feels entirely your own.
Managing expectations is a cornerstone of the Vie Aesthetics philosophy. Because regenerative aesthetics rely on your body’s biological response, results are gradual and vary between individuals. As highlighted in the feature on Polynucleotides explained by Harper’s Bazaar, these treatments are a commitment to long-term skin health rather than a quick change. Understanding the capabilities of skin boosters, profhilo, polynucleotides ensures you remain the lead architect of your own aesthetic journey.
Dr Ioannis Liakas emphasises the importance of a realistic approach: “At Vie Aesthetics, we believe in celebrating natural beauty. Our goal is to use regenerative science to support the skin’s own repair mechanisms, ensuring you look like a refreshed version of yourself rather than a different person entirely.”
These treatments excel at enhancing the quality of your skin from the inside out. You can expect a visible improvement in luminosity and what many describe as a “lit-from-within” dewiness. Whilst they aren’t fillers, the increased hydration and collagen stimulation can lead to a subtle tightening of mild skin laxity. The result is a natural-looking refresh that avoids the “pillow face” look sometimes associated with over-filled areas.
It’s vital to recognise the limitations of non-surgical injectables. These treatments won’t replace the structural lift provided by a surgical facelift or advanced laser procedures like Endolift. They don’t provide the dramatic volume or contouring of traditional dermal fillers, as their purpose is tissue quality rather than shape modification. Furthermore, results aren’t permanent; maintenance sessions are required to keep your cellular health at its peak.
Myth vs Reality
There is a common myth that results are “instant.” In reality, collagen synthesis is a biological process that takes time to unfold, typically showing the best results several weeks after your initial course. Another misconception involves the “salmon smell” of polynucleotides. Reality: the DNA fractions are ultra-purified and clinical-grade, meaning they are completely odourless and biocompatible.
Every successful skin journey begins with a detailed consultation. This essential first step allows us to understand your goals and assess the unique biology of your skin. We don’t believe in a one-size-fits-all approach; instead, we create a personalised plan that might incorporate skin boosters, profhilo, polynucleotides based on what your tissue specifically requires for a natural, refreshed glow.
Consistency is the secret to long-term results. To support your clinical treatments, we recommend the VieDerma Skincare Range for home maintenance. This ensures your skin remains nourished and protected between clinic visits. To make ongoing care more manageable, our Vie Membership scheme offers tiers from Bronze to Diamond, providing a structured way to prioritise your skin health throughout the year.
We believe that premium, doctor-led care should be accessible. For any treatment plans starting from £280, we offer interest-free finance options. This allows you to focus on your transformation whilst managing the investment at a pace that suits you. Our team is here to guide you through every stage, from the initial assessment to the final, glowing result.
In many cases, the most effective rejuvenation comes from combining different therapies. We often find that using Profhilo to address mid-face laxity whilst simultaneously using polynucleotides for the delicate under-eye area yields the most balanced outcome. This holistic strategy is at the heart of the “VieLift,” our signature combination approach that targets multiple layers of the skin for a comprehensive refresh. You can explore how we integrate these options in our comprehensive guide to non-surgical treatments.
Your safety is never compromised. At Vie Aesthetics, all injectable treatments are performed exclusively by doctors or qualified medical practitioners. This medical oversight ensures that every procedure is conducted with precision and a deep understanding of facial anatomy. Our 2023 CQC inspection, which highlighted our “Best Customer Service,” serves as a mark of the trust and safety we provide to every client who walks through our doors.
Choosing between skin boosters, profhilo, polynucleotides requires a clinical understanding of how your skin ages at a cellular level. We’ve explored how polynucleotides focus on deep tissue repair whilst Profhilo excels at bio-remodelling for improved elasticity. Both treatments offer a sophisticated path to rejuvenation without the need for traditional fillers or artificial volume. Your skin deserves a plan that respects its unique biology and your personal aesthetic goals.
At Vie Aesthetics, our CQC-regulated clinics prioritise your safety and professional integrity above all else. Every procedure is performed exclusively by medical doctors who specialise in creating bespoke, natural-looking transformations tailored to your anatomy. To make your journey even smoother, we provide interest-free finance options for treatments over £280. This ensures you can prioritise your skin health with complete peace of mind and financial flexibility.
You don’t have to navigate these choices alone. Our dedicated team is here to support you in finding the perfect match for your skin’s needs, ensuring you feel confident and empowered at every stage of your transformation.
The investment for these procedures depends on the specific brand of product selected and the number of sessions required for your individual goals. Most regenerative protocols involve an initial course of two or three treatments to build the necessary collagen and hydration. During your bespoke consultation, we provide a detailed plan and a clear breakdown of the costs involved. We also offer interest-free finance for plans over £280 to support your skin journey.
Results from these regenerative treatments are long-lasting but not permanent. Most patients enjoy the effects of Profhilo for approximately six months before a single maintenance session is recommended to sustain the tissue remodelling. Polynucleotides follow a similar timeline, with the cellular repair benefits typically lasting around six months. Individual lifestyle factors, such as sun exposure and skincare routines, will influence how long your skin maintains its improved resilience and hydration levels after your sessions.
Downtime is generally minimal, though you may experience slight swelling or small bumps at the injection sites for 24 to 48 hours. These bumps are simply the product settling into the dermis and usually dissipate quickly. Some patients might notice minor bruising, especially in the delicate under-eye area. We advise avoiding strenuous exercise, saunas, or heavy makeup for the first 24 hours to ensure the skin heals beautifully and without any unnecessary irritation or risk.
Yes, combining these treatments is often the most effective way to address multiple skin concerns simultaneously. Whilst Profhilo works to remodel the mid-face and improve overall laxity, polynucleotides can specifically target the thin skin around the eyes. This layered approach allows us to utilise the hydration of hyaluronic acid alongside the regenerative power of DNA fragments. Your doctor will design a bespoke schedule during your consultation to ensure each treatment has the space to work optimally.
Polynucleotides are derived from salmon DNA, so they are generally avoided if you have a known fish or seafood allergy. Whilst the DNA fractions undergo an ultra-purification process to remove proteins, safety remains our absolute priority. During your initial consultation, we’ll thoroughly review your medical history and allergies. If polynucleotides aren’t suitable, we can explore alternative skin boosters, profhilo, polynucleotides options that use hyaluronic acid to achieve similar hydrating and refreshing results safely.
For most skin boosters, profhilo, polynucleotides, an initial course is necessary to build the foundation for your results. Profhilo typically requires two sessions spaced four weeks apart. Polynucleotides often involve a course of three treatments at three-week intervals to achieve significant cellular repair. Whilst some patients notice a subtle improvement after the first visit, the full glow and improved skin texture usually become visible a few weeks after the final session of your specific treatment protocol.
